Key result
UCP3 promoter -55 C-->T variant shows no association with obesity.
Why the study?
Variability in the UCP3 promoter has been associated with increased BMI and altered lipid profiles, but its relationship to obesity and long-term body weight change is unclear.
Is the -55 C-->T polymorphism in the UCP3 gene promoter associated with increased BMI or long-term weight gain in the Danish population?
Observational (n=2,268)
Is the -55 C-->T polymorphism in the UCP3 gene promoter associated with increased BMI or long-term weight gain in the Danish population?
Absolute Event Rate: 26% vs 26.9%
p-value: p=0.6
The -55 C-->T polymorphism in the UCP3 gene promoter is not associated with common obesity or long-term weight gain in the Danish population.
Does not support UCP3 variant testing in obesity; leaves open contributions from other genetic factors.
Variability of the uncoupling protein 3 (UCP3) promoter has been associated with increased body mass index (BMI) and altered lipid profiles. Here we tested the hypothesis that variation of the UCP3 promoter is associated with either juvenile or maturity-onset obesity or body weight change over a 26-yr follow-up among Danish subjects. Mutation screening of approximately 1 kb 5' upstream of the UCP3 gene revealed one previously described -55 C-->T variant. The frequency of the polymorphism was evaluated by restriction fragment length polymorphism analysis in four groups of subjects: 1) a group of 744 obese Danish men who at the draft board examinations had a body mass index (BMI) of at least 31 kg/m(2), 2) a randomly selected control group consisting of 857 draftees, 3) 258 middle-aged subjects, and 4) 409 60-yr-old subjects. The frequency of the T allele was 26.0% (95% confidence interval, 23.8-28.2%) among the obese draftees and 26.9% (24.8-29.0%) in the control group (P = 0.6). The variant was not associated with BMI at a young age or with weight gain after a 26-yr follow-up. The frequency of the T allele was 29.5% (25.6-33.4%) in the middle-aged group and 25.8% (22.8-28.8%) among the 60-yr-old subjects. The polymorphism was not associated with increased BMI or percent body fat in these 2 groups. It is concluded that this variant does not play a major role in the development of common obesity among Danish subjects.
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Dalgaard et al. (2001) conducted an observational in Obesity (n=2,268). UCP3 promoter -55 C-->T variant vs. Control group (background frequency) was evaluated on T allele frequency in obese vs control draftees (p=0.6). The UCP3 promoter -55 C-->T variant was not associated with obesity, with a T allele frequency of 26.0% among obese draftees compared to 26.9% in controls (P=0.6).
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