Defeating cancer: the 150 most important questions in cancer research and clinical oncology

Despite all the human efforts and monetary investment over the last few decades, cancer is still a devastating threat to our life expectancy and quality of life in many parts of the world. The etiology of cancer varies. The genetic and epigenetic causes of cancer are heterogeneous and multifaceted. Early detection is still a difficult issue in many types of malignancies, resulting in unsatisfying cure rates. Cancer not only is a disease of malignant cells but also involves the host physiology, especially the natural defensive immune systems. The task of overcoming cancer is so vast and overwhelming that it will no doubt require scientists worldwide to join efforts and resources to succeed.