What question did this study set out to answer?

To assess the worldwide incidence, diagnostic timelines, clinical management approaches, and outcomes of acute mesenteric ischaemia.

January 23, 2024Critical CareOpen Access

Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study)

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Authors

ABAnnika Reintam Blaser MMMerli Mändul MBMartin Björck

Discussion

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Overview

Randomized trial reports high in-hospital mortality and extensive treatment variability in adults with acute mesenteric ischaemia, highlighting the need for standardized diagnostic pathways.

Key Points

To assess the worldwide incidence, diagnostic timelines, clinical management approaches, and outcomes of acute mesenteric ischaemia.
Multicentre interventional study (NCT05218863) conducted across 32 acute care hospitals between June 6, 2022, and April 5, 2023.
Enrolled N=705 adult patients with suspected acute mesenteric ischaemia (AMI), analyzing diagnostic delays, interventions, and 90-day survival.
AMI was confirmed in 418 of 705 suspected patients (0.038% of adult hospital admissions), comprising occlusive arterial (55.3%, n=231), venous (17.5%, n=73), non-occlusive (13.2%, n=55), and unclassified or other types (14.1%, n=59).
Symptom onset to hospital admission had a median delay of 24 h (IQR 9–48 h), whereas admission to diagnosis was 6 h (IQR 1–12 h); initial surgery occurred in 58% (n=242) with only 24.4% receiving surgical revascularization, while endovascular revascularization alone occurred in 13% (n=54).
Overall in-hospital and 90-day mortality rates were 49.0% and 53.3%, respectively, ranging from 13.7% and 16.4% for venous AMI to 72.7% and 74.5% for non-occlusive AMI.

Cite This Study

Blaser et al. (2024) studied this question.

synapsesocial.com/papers/6aaa45e297e8ffc3eb2aa881 https://doi.org/10.1186/s13054-024-04807-4

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January 23, 2024Critical CareOpen Access

Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study)

View Full Paper

Ask AI

Bookmark

Authors

ABAnnika Reintam Blaser MMMerli Mändul MBMartin Björck

Discussion

Member takes

Overview

Randomized trial reports high in-hospital mortality and extensive treatment variability in adults with acute mesenteric ischaemia, highlighting the need for standardized diagnostic pathways.

Key Points

To assess the worldwide incidence, diagnostic timelines, clinical management approaches, and outcomes of acute mesenteric ischaemia.
Multicentre interventional study (NCT05218863) conducted across 32 acute care hospitals between June 6, 2022, and April 5, 2023.
Enrolled N=705 adult patients with suspected acute mesenteric ischaemia (AMI), analyzing diagnostic delays, interventions, and 90-day survival.
AMI was confirmed in 418 of 705 suspected patients (0.038% of adult hospital admissions), comprising occlusive arterial (55.3%, n=231), venous (17.5%, n=73), non-occlusive (13.2%, n=55), and unclassified or other types (14.1%, n=59).
Symptom onset to hospital admission had a median delay of 24 h (IQR 9–48 h), whereas admission to diagnosis was 6 h (IQR 1–12 h); initial surgery occurred in 58% (n=242) with only 24.4% receiving surgical revascularization, while endovascular revascularization alone occurred in 13% (n=54).
Overall in-hospital and 90-day mortality rates were 49.0% and 53.3%, respectively, ranging from 13.7% and 16.4% for venous AMI to 72.7% and 74.5% for non-occlusive AMI.

Cite This Study

Blaser et al. (2024) studied this question.

synapsesocial.com/papers/6aaa45e297e8ffc3eb2aa881 https://doi.org/10.1186/s13054-024-04807-4

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