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Two pairs to win: Two pairs of iminodiacetic acid (Ida) moieties were incorporated in the leucine zipper segment of the GCN4-bZIP protein in such a way that the Ida moieties of each pair were in i and i+2 positions. Complex formation of the Ida groups with CoII led to destabilization of the helical structure and thus enabled reversible switching of the binding of the protein to the target AP-1 site (see picture).
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Azuma et al. (2009) studied this question.
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