Key result
Hypertension in uncontrolled T2D is linked to higher creatinine and lower GFR versus normotension.
Why the study?
Hypertension is a known risk factor for proteinuria and progression to end stage renal disease in patients with uncontrolled type 2 diabetes mellitus, but its effect on diabetic nephropathy progression requires further study.
Does hypertension accelerate the progression of diabetic nephropathy in patients with uncontrolled type 2 diabetes mellitus?
Observational (n=60)
Does hypertension accelerate the progression of diabetic nephropathy in patients with uncontrolled type 2 diabetes mellitus?
p-value: p=< 0.05
Uncontrolled hypertension in patients with uncontrolled type 2 diabetes is associated with a faster decline in renal function compared to normotensive patients.
Hypertension was associated with worse renal function in type 2 diabetes; leaves open whether BP control slows nephropathy progression.
Background: Hypertension is known to be risk factor for the development of proteinuria in patients with uncontrolled diabetes mellitus type2, leads to progression of end stage renal disease Aims & Objective: To study the effect of hypertension on diabetic nephropathy in type 2 diabetic patients. Material and Methods: We investigated, progression of diabetic nephropathy by measuring arterial blood pressure , serum creatinine and glomerular filtration rate(GFR) level in 60 (35 men and 25 women) type 2 uncontrolled diabetes mellitus patients on antihypertensive treatment. Results: The survey was done for 6 months during which 30 (group 1) -uncontrolled diabetes mellitus patients with normal blood pressure were compared with 30 (group 2) -Uncontrolled diabetes mellitus patients with hypertension who had mean systolic blood pressure (SBP) was 148.86 ± 5.12 mmHg. In group 2 the mean level of serum creatinine (1.71 ± 0.46 mg/dl) was significantly higher and mean GFR (54.57 ± 35.26 ml/min) was significantly lower than group 1 (P < 0.05). Conclusion: Uncontrolled hypertension leads to progression of diabetic nephropathy with decline in GFR earlier than normotensive uncontrolled diabetic patients.
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Dodhia et al. (2012) conducted an observational in Type 2 uncontrolled diabetes mellitus (n=60). Hypertension vs. Normal blood pressure was evaluated on Progression of diabetic nephropathy (measured by serum creatinine and glomerular filtration rate) (p=< 0.05). Hypertension in patients with uncontrolled type 2 diabetes was associated with significantly higher serum creatinine and lower GFR compared to normotensive patients (P < 0.05).
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