Population
Eight-week-old male Wistar rats
Comparison
High caloric diet for 16 weeks vs Age-matched lean controls
Design
Preclinical
Follow-up
16 weeks
Key result
A high caloric diet in rats induced pre-diabetes, leading to attenuated baseline contractile function, increased myocardial infarct sizes, and diminished ADP phosphorylation rates compared to controls.
Authors
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Pre-diabetic mitochondrial impairment may underlie early cardiac dysfunction; leaves open relevance to human ischemia tolerance and cardiomyopathy.
In a rat model of pre-diabetes, a high caloric diet decreases mitochondrial bioenergetic capacity, which impairs basal contractile function and reduces tolerance to acute oxygen deprivation.
Essop et al. (2009) studied Pre-diabetes. High caloric diet vs. Age-matched lean controls was evaluated on Cardiac function and mitochondrial respiratory capacity. A high caloric diet in rats induced pre-diabetes, leading to attenuated baseline contractile function, increased myocardial infarct sizes, and diminished ADP phosphorylation rates compared to controls.