Why the study?
Does streptozotocin-induced diabetes impair mitochondrial respiratory function and Ca2+ uptake in rat hearts?
Population
Streptozotocin (55 mg/kg)-induced diabetic rats (model of insulin-dependent diabetes mellitus)
Comparison
Streptozotocin (55 mg/kg) to induce diabetes vs Control rats
Design
Preclinical
Follow-up
2 to 4 weeks
Authors
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May link early mitochondrial Ca2+ defects to diastolic dysfunction in diabetic rat hearts; leaves open relevance to human disease.
Does streptozotocin-induced diabetes impair mitochondrial respiratory function and Ca2+ uptake in rat hearts?
Diabetic cardiomyopathy in rats is associated with impaired mitochondrial Ca2+ uptake and reduced capacity to upregulate ATP synthesis, contributing to diastolic dysfunction.
Flarsheim et al. (1996) studied this question.
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