Why the study?
Does insulin treatment improve mitochondrial respiratory impairment in streptozotocin-induced diabetic rat hearts?
Population
Male Wistar rats with diabetes mellitus induced by intravenous injection of streptozotocin (STZ)
Comparison
Insulin injection for 2 or 3 weeks prior to… vs Diabetic rats without insulin treatment and…
Design
Preclinical
Follow-up
2 to 16 weeks
Key result
Streptozotocin-induced diabetes reduced mitochondrial state 3 respiration to 59.1% of control, and complex I and V activities to 43.4% and 71.7%, all of which recovered with insulin treatment.
Authors
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Insulin may restore mitochondrial function in diabetic rat hearts; hypothesis-generating and should not change practice.
Does insulin treatment improve mitochondrial respiratory impairment in streptozotocin-induced diabetic rat hearts?
In a diabetic rat model, impaired oxidative phosphorylation due to depressed complex I and V activities contributes to cardiac mitochondrial dysfunction, which is reversible with insulin treatment.
Tomita et al. (1996) studied Diabetes mellitus. Streptozotocin (STZ) vs. Control and insulin-treated diabetic rats was evaluated on Mitochondrial state 3 respiration. Streptozotocin-induced diabetes reduced mitochondrial state 3 respiration to 59.1% of control, and complex I and V activities to 43.4% and 71.7%, all of which recovered with insulin treatment.