Key result
Intravenous paclitaxel induces ST-elevation ACS that resolves immediately with sublingual nitroglycerine.
Why the study?
Paclitaxel-induced acute coronary syndrome with ST-segment elevations despite standard premedication is a clinical observation requiring documentation.
Case Report (n=1)
Intravenous paclitaxel can induce acute coronary syndrome with ST-segment elevations, which may be reversible with nitroglycerine.
Hypothesis-generating case of paclitaxel-associated reversible ST-elevation ACS; leaves open need for systematic evaluation in larger cohorts.
A 51-year-old woman presented with severe chest pain minutes after starting intravenous paclitaxel as a part of the systemic chemotherapy due to ovarian carcinoma. The electrocardiogram (ECG) revealed sinus rhythm with ST-segment elevations in inferior and anterior leads. The ST-segment elevations resolved immediately after sublingual nitroglycerine. Cardiac troponin T and CPK MB levels remained in the normal range at repeat measurements. It was presumed that in spite of standard premedication, paclitaxel had induced acute coronary syndrome with ST-segment elevations in this patient.
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Gemici et al. (2009) conducted a case report in Ovarian carcinoma (n=1). Intravenous paclitaxel was evaluated on Acute coronary syndrome with ST-segment elevations. Intravenous paclitaxel induced acute coronary syndrome with ST-segment elevations in a 51-year-old woman, which resolved immediately after sublingual nitroglycerine.
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