Growing impact of Herbal Bioenhancers in Pharmaceutical Industries A Comprehensive Review

Bioenhancers are the drug facilitators which are combined with some drug in order increase the activity of a drug molecule without affecting its properties and making it biologically available across the membrane for target cells to be used. They are an efficient source to reduce the drug dosage and toxicity, major causes of drug resistance, and ultimately play a vital role in the treatment of various disorders. They have shown to increase the bioefficacy in combination with antibiotics, antiviral, antifungal, anticancer and antituberculosis drugs at lower doses. When they come from any herbal origin, they are known as herbal bioenhancers. Many herbal compounds e.g. quercetin, genistein, naringin, sinomenine, piperine, glycyrrhizin, nitrile glycoside, allicin, gallic acid and capsaicin etc. have been established to illustrate bioenhancing activity of various drugs. Herbal Bioenhancers are safe, effective, economical and easily procurable molecules with a broad-spectrum impact. However regarding their mechanism of action the exact mechanism still needs to be elucidated but current literature suggests their mechanism of action is mainly through absorption, drug metabolism and dose reduction. In conclusion their application may ultimately have a positive influence on the national economy of a country.