Key result
Intravenous cocaine in rats reveals coupled CBV and BOLD signals during graded brain activation.
Why the study?
It was unclear whether changes in cerebral blood volume and BOLD signal were regionally coupled and how their sensitivities compared across different brain structures during brain activation.
Are changes in CBV and BOLD signal regionally coupled in rat brain parenchyma following intravenous cocaine injection?
Are changes in CBV and BOLD signal regionally coupled in rat brain parenchyma following intravenous cocaine injection?
In a rat model, CBV and BOLD signal changes are spatially and temporally coupled during brain activation, and contrast agents enhance functional MRI sensitivity.
Functional MRI of rat brain was performed at 2 Tesla following intravenous injection of cocaine in order to 1) determine if changes in CBV and changes in BOLD signal were regionally coupled in brain parenchyma, and 2) compare the sensitivities of these imaging methods across different brain structures. Percent changes in CBV and BOLD relaxation rate were spatially and temporally coupled during this graded brain activation. The use of contrast agent increased functional sensitivity in all parenchymal brain structures, with a strong but predictable dependence on the resting-state blood volume fraction. Magn Reson Med 45:443-447, 2001.
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Mandeville et al. (2001) studied Rat brain stimulation. Intravenous injection of cocaine was evaluated on Coupling of CBV and BOLD signal changes and sensitivity across brain structures. Intravenous injection of cocaine in rats demonstrated that percent changes in CBV and BOLD relaxation rate were spatially and temporally coupled during graded brain activation.
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