CBF and CBV changes were measured sequentially, in regions of positive and negative BOLD responses, using a multi-echo center-out readout, known to reduce BOLD contaminations in pCASL and VASO measurements due to its short echo times. The CBV-CBF coupling was found to differ between positive and negative BOLD regions. The temporal relation of the CBF and VASO timecourses to their corresponding T2* timecourses, on the other hand, was found to be almost identical in the two ROIs.
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Devi et al. (2024) studied this question.
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