Key result
Cortical hypometabolism on 3-month follow-up PET is linked to higher rates of developmental delay.
Why the study?
The prognostic value of positron emission tomography in infants with cryptogenic West syndrome was unclear.
Does positron emission tomography (PET) predict developmental or seizure outcomes in infants with cryptogenic West syndrome?
Cohort (n=17)
Does positron emission tomography (PET) predict developmental or seizure outcomes in infants with cryptogenic West syndrome?
p-value: p=<0.05
PET imaging performed after initial treatment may be a useful prognostic tool for predicting developmental outcomes in infants with cryptogenic West syndrome.
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Post-treatment PET hypometabolism was associated with higher developmental delay risk in cryptogenic West syndrome; leaves open whether serial PET refines prognosis.
Itomi et al. (2002) conducted a cohort in Cryptogenic West syndrome (n=17). Cortical hypometabolism on second PET scan vs. No PET abnormalities on second PET scan was evaluated on Rate of developmental delay at the last follow-up (p=<0.05). Cortical hypometabolism on a second PET scan 3 months after initial therapy was associated with a significantly higher rate of developmental delay at follow-up (p<0.05).
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