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Lithium is distinguished by its therapeutic action in mania and its prophylactic action in recurrent manic-depressive disorder of the bipolar and unipolar type. By prophylactic action is meant the ability to attenuate or prevent manic and depressive recurrences. Lithium has a relatively low therapeutic index, and knowledge of its pharmacology and toxicology is important for safe and effective usage.
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Mogens Schou (1976) studied this question.
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