Key result
First-day calcium and PTH fail to predict safe thyroidectomy discharge, risking a ~27% error rate.
Why the study?
It is important to predict which patients will not develop hypocalcemic complications after total thyroidectomy to enable safe early discharge.
Can preoperative and postoperative day 1 serum calcium and PTH levels predict which patients can be safely discharged 24 hours after total thyroidectomy without hypocalcemic complications?
Observational (n=327)
Can preoperative and postoperative day 1 serum calcium and PTH levels predict which patients can be safely discharged 24 hours after total thyroidectomy without hypocalcemic complications?
Serum calcium and PTH levels on the first postoperative day cannot reliably predict which patients can be safely discharged 24 hours after total thyroidectomy without risk of hypocalcemia.
Should not guide 24-hour discharge decisions after thyroidectomy; leaves open need for validated predictors in prospective studies.
AIM: The continued hospitalization after total thyroidectomy is often due to the onset of hypocalcemic complications more than 24 hours after surgery. So it would be important to predict which patients will not develop the hypocalcemic complication to discharge them early. This was the aim of our study. PATIENTS AND METHODS: Our retrospective study was conducted on 327 consecutive thyroidectomized patients, operated on for benign and malignant diseases. We evaluated the values of preoperative serum calcium levels (Cal0) and of the first postoperative day (Cal1) and two new variables were calculated (dCal and dCaln). The same thing was made on a subgroup of 111 patients in whom also parathiroyd hormone (PTH) values were detected. Statistical analysis was performed with the goal of determining if we could establish a safe criterion for discharge at 24 hours after surgery and if there is a correlation between suitability for discharge and diagnosis. RESULTS: As to discharge, the predictive power of the discriminant function applied was significant both on the total of patients and in the subgroup of 111 patients, but it was clinically unacceptable because it would expose us to a 21% to 27% error rate. It is not possible to identify a threshold, below which to consider patients surely dischargeable. The diagnosis does not appear correlated with the suitability for discharge. CONCLUSION: On the basis of serum calcium and PTH levels in the first postoperative day, it is impossible to predict which patients can be discharged 24 hours after surgery without incurring in hypocalcemic complications.
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Francesco Tartaglia (2016) conducted an observational in Benign and malignant thyroid diseases (n=327). Serum calcium and PTH levels on the first postoperative day was evaluated on Suitability for safe discharge at 24 hours after surgery without hypocalcemic complications. Predicting safe discharge 24 hours after total thyroidectomy using first postoperative day serum calcium and PTH levels is clinically unacceptable, exposing patients to a 21% to 27% error rate.
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