Key result
Acute MI is linked to a 24-hour increase in plasma FFAs that normalizes by day 7.
Why the study?
There has been a constant search for different parameters for the diagnosis and management of coronary artery diseases including acute myocardial infarction.
Does plasma free fatty acid concentration increase in patients with acute myocardial infarction compared to healthy controls?
Case-Control (n=100)
Does plasma free fatty acid concentration increase in patients with acute myocardial infarction compared to healthy controls?
Plasma free fatty acid concentrations are significantly elevated in the first 24 hours of acute myocardial infarction and normalize by day 7, suggesting potential utility as a diagnostic biomarker.
BACKGROUND: Acute myocardial infarction carries a high mortality among cardiac patients.The discovery of the fact that certain enzymes like CPK, LDH liberated into circulation following necrosis of the myocardial cells came as boon for physicians and patients. There has been a constant search of different parameters for the diagnosis and management of CoronaryArtery Diseases (CAD). AIM: The present study was undertaken to investigate a possible relation between the changes in plasma free fatty acid (FFA) concentration and acute myocardial infarction. MATERIAL AND METHODS: Fifty cases (25 males and 25 females) of acute myocardial infarction were selected for the present study. All the patients were in the age group of 40-70 years. For the control group fifty (25 male and 25 female) subjects of same age group were selected from patient's relatives and friends. Plasma free fatty acid concentration was estimated by Titrametric method of Trout et al., (1960), a modified version of Dole (1956). STATISTICAL ANALYSIS: The statistical analysis of the data of the present study was done by using SPSS, version 14.0.1 was used. RESULTS: Our study showed a significant increase in plasma FFA in the first 24 hours of acute myocardial infarction with subsequent normalisation on the 7th day.The difference between the first and the seventh day was statistically significant. CONCLUSION: The FFA were found raised in cases of acute myocardial infarction.On the basis of present study, it is worth to say that estimation of serum free fatty acid should be done routinely at the earliest opportunity in all cases of acute myocardial infarction.
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Vijay Kumar Roy (2013) conducted a case-control in Acute myocardial infarction (n=100). Acute myocardial infarction vs. Healthy controls was evaluated on Plasma free fatty acid concentration. Acute myocardial infarction was associated with a significant increase in plasma free fatty acid concentrations in the first 24 hours, which normalized by the 7th day.
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