Key result
Total (+)-propranolol clearance strongly correlates with hepatic blood flow to accurately estimate basal flow.
Why the study?
Accurate estimation of basal hepatic blood flow in humans with normal liver function is needed, and (+)-propranolol clearance may serve as a measure.
Does (+)-propranolol clearance accurately estimate basal hepatic blood flow in patients with suspected renal hypertension and normal liver function?
Population
19 patients with suspected renal hypertension and normal liver function
Comparison
Hepatic blood flow before and during (+)- and (+/-)-propranolol administration
Design
Physiological study measuring hepatic blood flow and propranolol clearance
Authors
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May support noninvasive hepatic blood flow estimation in normal liver function; leaves open validation in renal hypertension.
Does (+)-propranolol clearance accurately estimate basal hepatic blood flow in patients with suspected renal hypertension and normal liver function?
Effect estimate: r = +0.86
p-value: p=<0.01
Total clearance of (+)-propranolol provides an accurate estimation of basal hepatic blood flow in subjects with normal liver function.
Weiss et al. (1978) studied Suspected renal hypertension and normal liver function (n=19). (+)- and (+/-)-propranolol vs. Baseline (before administration) was evaluated on Relationship between hepatic blood flow and (+)-propranolol clearance (r = +0.86, p=<0.01). Total clearance of (+)-propranolol showed a highly significant positive relationship with hepatic blood flow (r = +0.86; P<0.01), providing an accurate estimation of basal hepatic blood flow.
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