A functional systems approach to understanding verbal-motor integration in individuals with Down syndrome

In this paper we present the background, development and application of a functional systems approach to understanding verbal-motor integration characteristic of persons with Down syndrome. Based on our initial work utilising noninvasive, neuropsychological procedures, we have forwarded a specific model of brain-behaviour relations in persons with Down syndrome. The crucial characteristic of the model is the proposed functional disconnection of brain areas responsible for speech perception and movement organisation. In addition to describing the model, we summarize our recent work designed to test, refine, and extend it.