Key result
CAD is linked to lower resting maximum systolic velocity on TDI compared to no CAD.
Why the study?
Tissue Doppler imaging has emerged as an adjunct tool for diagnosing regional wall motion abnormalities from CAD, but its efficacy compared to conventional methods was unclear.
Do Tissue Doppler imaging (TDI) indices differ between patients with and without angiographically confirmed coronary artery disease?
Population
Patients with and without CAD confirmed by coronary angiography in 8 studies
Comparison
TDI measurements in patients with CAD versus without CAD
Design
Systematic review and meta-analysis of controlled studies
Authors
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May support adjunctive TDI for CAD evaluation; leaves open prospective validation before practice change.
Systematic Review (n=568)
Do Tissue Doppler imaging (TDI) indices differ between patients with and without angiographically confirmed coronary artery disease?
Mean Difference: -0.66 (95% CI -0.98–-0.34)
Tissue Doppler imaging indices, specifically resting maximum systolic velocity and post-stress diastolic velocities, are significantly reduced in patients with coronary artery disease, suggesting a potential adjunctive role in CAD evaluation.
Agarwal et al. (2012) conducted a systematic review in Coronary artery disease (n=568). Coronary artery disease vs. No coronary artery disease was evaluated on Maximum systolic velocity at rest (MD -0.66, 95% CI -0.98 to -0.34). At rest, coronary artery disease was associated with a significant decrease in pooled maximum systolic velocity on tissue Doppler imaging compared to patients without CAD (MD -0.66).
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