Key result
Higher BMI linked to increased LAVOL and LVMI yielding allometric correction exponents of ~1.
Why the study?
Isometric indexation of cardiac structures fails in patients with overweight, motivating the evaluation of cardiac dimensions across normal and high BMI categories to determine allometric correction exponents.
Does allometric correction provide better indexation of cardiac structures than isometric indexation in patients with high BMI?
Cross-Sectional (n=430)
Does allometric correction provide better indexation of cardiac structures than isometric indexation in patients with high BMI?
Allometric correction is superior to isometric indexation for assessing left atrial volume and left ventricular mass index in overweight and obese patients, helping differentiate obesity-related changes from true pathology.
Hypothesis-generating for allometric indexation of LAVOL and LVMI in obesity; should not yet change practice over isometric methods.
AIMS: Isometric indexation of cardiac structures fails in patients with overweight. The aim of the study was to evaluate the LA indexed volume (LAVOL), left ventricular end-diastolic diameter (LVEDD), left ventricular mass index (LVMI), and the aortic sinus diameter (AOSD) in healthy subjects with normal and high BMI and find the allometric correction exponent. METHODS: Four hundred and thirty patients without cardiac pathology were analyzed. Patients were divided into groups: Group I BMI < 24.9 187 patients, Group II BMI 25-29.9 154 patients, Group III BMI 30-34.9 63 patients, and Group IV 35-39.9 26 patients. A Doppler echocardiogram was performed. The parameters indexed were compared between groups. When allometric growth was verified, the allometric coefficient was calculated. RESULTS: : .39) were observed. A significant increase was observed in LAVOL and LVMI in the groups with increased BMI. We observed a decrease in the indexed AOSD and a marginal difference between groups in LVEDD. The allometric correction exponent calculated was as follows: LAVOL: 0.96 and for LVMI: 0.97. CONCLUSIONS: Allometric correction is superior to isometric indexation to assess LAVOL and LVMI in obese and overweight patients. Allometric correction would allow differentiating deviations from VOLAI and IMVI attributable to obesity from those attributable to an associated pathology.
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Carnevalini et al. (2020) conducted a cross-sectional in High body mass index (n=430). High body mass index vs. Normal body mass index (BMI < 24.9) was evaluated on Allometric correction exponent for LA indexed volume (LAVOL) and left ventricular mass index (LVMI). Increased BMI in healthy subjects was associated with significant increases in LAVOL and LVMI, yielding calculated allometric correction exponents of 0.96 and 0.97, respectively.
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