Key result
CT mosaic pattern occurs in ~18% of PH patients, linking to larger PAs and perfusion defects.
Why the study?
There is limited published data on chest CT findings, specifically mosaic pattern of lung attenuation, when used to evaluate pulmonary hypertension.
Does the presence of a mosaic pattern on chest CT correlate with specific subtypes or severity of pulmonary hypertension?
Observational (n=189)
Does the presence of a mosaic pattern on chest CT correlate with specific subtypes or severity of pulmonary hypertension?
A mosaic pattern on chest CT is present in 18% of patients with pulmonary hypertension and correlates with PA size and perfusion defects, but is not specific enough to distinguish PH subtypes.
Answers are grounded in this paper and cite their sources.
Mosaic CT pattern was associated with PH severity markers but not subtypes; leaves open its diagnostic utility.
A mosaic pattern of lung attenuation on chest computed tomography (CT) may be due to various etiologies. There is limited published data on CT results when used to evaluate pulmonary hypertension (PH). We retrospectively studied the frequency of mosaic pattern in patients with PH and the cause of the PH by diagnostic group, as well as the correlation between the mosaic pattern and the following: demographics, severity of the PH, main pulmonary artery (PA) size, PA/aorta (PA/Ao) ratio, pulmonary function tests (PFT), and ventilation perfusion scan results. Overall, 18% of the cohort had CT mosaic pattern (34/189). Mosaic pattern was present in 17/113 (15%) in Group 1 pulmonary arterial hypertension, 5/13 (28%) in Group 2 pulmonary venous hypertension and 8/50 (16%) in Group 3 PH. Conversely, Group 4 chronic thromboembolic PH was more prevalent in 4/8 (50%). Main PA size, PA/Ao ratio, and segmental perfusion defect were positively associated with mosaic pattern. In contrast, factors such as age, gender, body mass index, functional class, hemodynamic data, and PFT values were not associated with mosaic pattern. Mosaic pattern is not specific as an isolated finding for distinguishing the subtype of PH.
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Ussavarungsi et al. (2015) conducted an observational in Pulmonary Hypertension (n=189). Mosaic pattern of lung attenuation on chest CT was evaluated on Frequency of CT mosaic pattern. A mosaic pattern on chest CT was present in 18% of patients with pulmonary hypertension and was positively associated with main pulmonary artery size, PA/aorta ratio, and perfusion defects.
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