Calponin 1 Serum Level A Biological Marker for Preterm Labor Predictability

Aim: To evaluate and assess the value of measuring calponin 1 serum level in maternal circulation as a predictability tool for preterm labor within 1 week in cases affected with threatened preterm delivery.Methodology: cases clinically presenting at 24-34 gestational weeks with threatened preterm labor undergone sample collection for measuring calponin 1 serum level simultaneously with cervical length assessment.With follow up performed in a prospective manner till time of birth assessment and perinatal clinical outcomes of recruited subjects have been collected and tabulated for analysis.Results: One hundred forty-seven patients affected by threatened preterm labor symptoms, between ‫42‬ and ‫33‬ + 6gestational weeks have been enrolled in the research study.71cases (48.3%) delivered within 1 week from admission (group-A) and the remaining 76 cases (51.7%) delivered after 1 week from admission (group-B).Statistical correlations between the time interval between admission and delivery and cervical length& calponin-1 at admissions were significantly positive (0.387, p<0.001) & significantly negative (-0.470, p<0.001) respectively while it was between cervical length and calponin-1 at admissions significantly negative (-0.413, p<0.001).Cervical length and calponin-1 at admissions had moderate Diagnostic performance in predicting delivery within 1 week from admission that not markedly increased if having any of them or by combination in a regression equation.Conclusion: measuring and evaluating calponin 1 level in maternal serum could be a useful biological marker in short-range time period for predictability of preterm delivery within patients affected by threatened preterm delivery clinical presentation, besides cervical length dimension measuring.