Key result
Self-expanding valves show no mortality benefit over balloon-expandable valves but are linked to higher PPI risk.
Why the study?
The effect of valve type on outcomes in transfemoral transcatheter aortic valve replacement had recently been a subject of debate.
Do self-expanding transcatheter heart valves compared to balloon-expanding valves improve in-hospital outcomes in patients undergoing TF-TAVR?
Cohort (n=17,295)
Yes
Do self-expanding transcatheter heart valves compared to balloon-expanding valves improve in-hospital outcomes in patients undergoing TF-TAVR?
Odds Ratio: 0.94 (95% CI 0.76–1.17)
Absolute Event Rate: 2.21% vs 2.32%
p-value: p=0.617
Self-expanding and balloon-expandable valves demonstrate equivalent in-hospital mortality and major complications in TF-TAVR, though self-expanding valves carry a higher risk of permanent pacemaker implantation.
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SE valves linked to higher PPI risk but otherwise similar in-hospital outcomes; leaves open optimal choice pending randomized confirmation.
Stachon et al. (2021) conducted a cohort in Aortic stenosis (n=17,295). Self-expanding transcatheter heart valves vs. Balloon-expandable transcatheter heart valves was evaluated on In-hospital mortality (aOR 0.94, 95% CI 0.76-1.17, p=0.617). Self-expanding transcatheter heart valves showed no significant difference in in-hospital mortality compared to balloon-expandable valves (aOR 0.94, p=0.617), but were associated with a higher risk of permanent pacemaker implantation.
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