Key result
Sustained hypoxia drives greater HRV reduction and pre-frontal cortex deoxygenation than intermittent hypoxia.
Why the study?
Whether sustained hypoxia (SH) and intermittent hypoxia (IH) conditioning induce different physiological responses in healthy subjects remains to be elucidated.
Does sustained hypoxia compared to intermittent hypoxia induce different physiological responses in healthy subjects?
Comparison
Sustained hypoxia (SH) vs intermittent hypoxia (IH) conditioning
Design
Single-blind randomized cross-over trial
Follow-up
3 sessions per intervention, 48 h apart, separated by 2 week washout
Authors
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SH and IH elicit distinct acute cardiorespiratory and oxygenation responses; leaves open optimal protocols for therapeutic use in patients.
RCT (n=14)
Single-blind
Block randomization
No
Does sustained hypoxia compared to intermittent hypoxia induce different physiological responses in healthy subjects?
p-value: p=<0.001
Short-term sustained and intermittent hypoxic conditioning interventions induce significantly different changes in heart rate variability, blood pressure, and tissue oxygenation in healthy subjects.
Chacaroun et al. (2017) conducted an RCT in Healthy (n=14). Sustained hypoxia (SH) vs Intermittent hypoxia (IH) vs. Cross-over (each subject performed both interventions) was evaluated on Heart rate variability (SDNN) and tissue oxygenation differences between conditions (p=<0.001). Sustained hypoxia conditioning induced a significantly larger reduction in heart rate variability and greater pre-frontal cortex deoxygenation compared to intermittent hypoxia in healthy subjects.
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