concentrations in plasma (Table S4).The highest plasma concentration of tecovirimat after one dose was 200 to 1000 times as high as the IC 50 values for the agent.The plasma concentrations of brincidofovir were 3.9 to 67.0 times as high as the IC 50 values, and the plasma concentrations of cidofovir were 2.5 to 16.0 times as high as the IC 50 values.Our data indicate that the currently circulating MPXVs are likely to remain sensitive to the available antiviral drugs.
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Mata et al. (2023) studied this question.
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