Key result
COPD patients show greater circadian rhythm fragmentation and lower relative amplitude versus healthy controls.
Why the study?
Circadian rest-activity rhythm characteristics in COPD patients were not well characterized.
Does chronic obstructive pulmonary disease alter circadian rest-activity rhythms compared to healthy controls?
Case-Control (n=41)
Does chronic obstructive pulmonary disease alter circadian rest-activity rhythms compared to healthy controls?
Absolute Event Rate: 0.242% vs 0.182%
Patients with COPD exhibit more fragmented circadian rest-activity rhythms and lower relative amplitude compared to healthy controls.
COPD rhythm fragmentation on actigraphy warrants no practice change; leaves open whether chronotherapy improves outcomes in larger trials.
To characterize circadian rest-activity rhythm in COPD, 26 cases (66.9 ± 8.5y) and 15 controls (63.0 ± 10.7y) were assessed by actimetry. Rhythm fragmentation was measured by intradaily variability (IV), while synchronization to the 24-h light-dark cycle was measured by interdaily stability (IS). The average activity during the least active 5-h period (L5) and the average activity during the most active 10-h period (M10) were used to calculate the relative amplitude mean [RAm = (M10-L5)/(M10+L5)]. COPD patients presented higher IVm (0.242 ± 0.097 vs 0.182 ± 0.063) and L5 (36.849 ± 18.239 vs 19.888 ± 12.268) and lower RAm (0.696 ± 0.134 vs 0.833 ± 0.093) than controls. Future studies on the effects of chronotherapy measures in COPD are warranted.
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Nunes et al. (2017) conducted a case-control in Chronic obstructive pulmonary disease (n=41). Chronic obstructive pulmonary disease vs. Controls was evaluated on Intradaily variability mean (IVm). COPD patients presented higher rhythm fragmentation (IVm 0.242 vs 0.182) and lower relative amplitude (RAm 0.696 vs 0.833) than controls.
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