Key result
Active cancer linked to ~72% higher brown adipose tissue SUV versus no active cancer.
Why the study?
The study aimed to compare brown adipose tissue activity on 18F-FDG PET/CT between patients with and without active cancer.
Does active cancer status correlate with increased brown adipose tissue activity on 18F-FDG PET/CT in oncology patients?
Observational (n=78)
No
Does active cancer status correlate with increased brown adipose tissue activity on 18F-FDG PET/CT in oncology patients?
Brown adipose tissue activity on 18F-FDG PET/CT is significantly higher in patients with active cancer, suggesting a potential role of adipose tissue activation in cancer progression.
Answers are grounded in this paper and cite their sources.
Higher BAT activity observed in active cancer may reflect association only; leaves open any causal role in oncogenesis.
Aim: In this study, we aimed to compare brown adipose tissue (BAT) activity on 18F-Flourodeoxyglucose Positron Emission Tomography (PET)/Computed Tomography(CT) in patients with and without active cancer. Material and Methods: Results of the patients who underwent 18F-FDG PET/CT between January 2014 and February 2018 in Nuclear Medicine Department were evaluated retrospectively. Age, gender, body mass index (BMI), serum levels of glucose, bilirubin, total cholesterol (T-chol), low-density lipoprotein (LDL) and triglyceride (TG) of the patients were noted from the hospital database. Mean outdoor temperature of the day during PET/CT imaging was searched from National Weather Service archives. Diagnosis and disease activity status on PET/CT imaging were evaluated retrospectively. Standardized uptake value (SUV) and brown adipose tissue volume (BAV) were calculated on PET/CT images. Additionally, hepatic attenuation index and subcutaneous adipose tissue thickness (SCATT) were calculated from CT images. Difference between median SUV and BAV among groups with and without active cancer was analyzed. Results: Totally 78 (54 F; 24 M; mean age 34.415.6) patients who underwent 18F-FDG PET/CT for different oncological indications were included in the analysis. All the patients had different degrees of BAT uptake on PET/CT images. Median (min-max) values for SUV, BAV and SCATT were found as 8.0 (2.7-37.0), 26.9 (2.1- 116.0) cm3 and 15.0 (3.0- 46.0) mm, respectively. Hepatic attenuation index was 0-5%, 6-30% and >30% in 56 (71%), 20 (26%) and 2 (3%) patients, respectively. Active disease was observed in 26 (33%) patients during PET/CT imaging. In the evaluation of the distribution of the adipose tissue parameters, median SUV (p=0.008) and BAV (p=0.008) of groups with and without active cancer were found statistically significant. Conclusion: BAT activity in patients with active cancer seems to be higher than that in patients without active disease, supporting the possible role of adipose tissue activation on cancer development and progression.
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Araz et al. (2022) conducted an observational in Oncological indications with brown adipose tissue uptake (n=78). Active cancer vs. No active cancer was evaluated on Median standardized uptake value (SUV) of brown adipose tissue (p=0.008). Patients with active cancer had significantly higher median brown adipose tissue standardized uptake values (12.2 vs 7.1, p=0.008) and volumes (44.1 vs 21.0 cm3) than those without active cancer.
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