Key result
Absence of brown adipose tissue on PET-CT linked to ~212% higher likelihood of NAFLD.
Why the study?
Is the presence of brown adipose tissue associated with a lower likelihood of non-alcoholic fatty liver disease in adult humans?
Case-Control (n=120)
Is the presence of brown adipose tissue associated with a lower likelihood of non-alcoholic fatty liver disease in adult humans?
Odds Ratio: 3.12 (95% CI 1.03–9.88)
p-value: p=<0.05
The presence of active brown adipose tissue in adults is independently associated with a lower likelihood of CT-diagnosed non-alcoholic fatty liver disease.
Supports BAT-NAFLD association in adults; leaves open causality and interventional potential in prospective studies.
BACKGROUND: The presence of active brown adipose tissue (BAT) has been associated with a reduced risk of obesity in adult humans. AIM: To examine whether the presence and activity of BAT in patients undergoing PET-CT examinations is related to the presence of fatty liver. METHOD: We retrospectively analysed 3666 consecutive PET-CT whole-body scans performed on a total of 1832 patients who were referred for suspected malignancies. BAT-positive subjects (BAT+) were defined as subjects who showed substantial amounts of brown adipose tissue on PET-CT scans. In areas where uptake of [(18)F]FDG was identified by CT for BAT, the maximal standardised uptake values (SUVmax), defined as the maximum activity per millilitre within the region of interest divided by the injected dose in megabecquerels per gram of body weight, were determined. A ratio of mean liver attenuation to spleen attenuation <0.8 on CT scans was considered to indicate NAFLD. RESULTS: Thirty patients of the 1832 screened individuals (2%) demonstrated brown fat uptake (BAT+ subjects). Ninety matched individuals without evidence of BAT on PET scans (BAT- subjects) were enrolled for comparison purposes. After adjustment for potential confounders, the odds ratio for having NAFLD was significantly higher for BAT- subjects (3.12, 95% confidence interval = 1.03-9.88, P < 0.05). The SUVmax for brown fat tissue was significantly correlated with the ratio of mean liver attenuation to spleen attenuation (P < 0.05). CONCLUSION: The presence of brown adipose tissue in adulthood is independently associated with a lower likelihood of NAFLD diagnosed by CT findings.
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Yılmaz et al. (2011) conducted a case-control in Suspected malignancies (n=120). Absence of brown adipose tissue (BAT-) vs. Presence of brown adipose tissue (BAT+) was evaluated on Non-alcoholic fatty liver disease (NAFLD) (OR 3.12, 95% CI 1.03-9.88, p=<0.05). The absence of brown adipose tissue on PET-CT was significantly associated with a higher likelihood of non-alcoholic fatty liver disease (OR 3.12; 95% CI 1.03-9.88; P<0.05).
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