May 26, 2011The Journal of Clinical Endocrinology & MetabolismOpen Access

High Prevalence of Brown Adipose Tissue in Adult Humans

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Why the study?

Is brown adipose tissue present in PET-negative supraclavicular fat in adult humans?

Population

17 patients who underwent preoperative PET-CT for staging of head and neck malignancy

Comparison

Biopsy of supraclavicular fat vs Subcutaneous fat (negative control)

Design

Cohort

Authors

PLPaul LeeChinese University of Hong Kong JZJing ZhaoNorthwestern University MSMichael M. SwarbrickThe University of Sydney

Discussion

Member takes

Implication

PET-CT may underestimate adult BAT prevalence; leaves open optimal detection methods and functional assessment.

Structured PICO

Is brown adipose tissue present in PET-negative supraclavicular fat in adult humans?

Population

17 patients who underwent preoperative PET-CT for staging of head and neck malignancy

Intervention

Biopsy of supraclavicular fat (PET-positive and PET-negative)

Comparator

Subcutaneous fat (negative control)

Outcome

Signature BAT gene transcripts and protein in biopsies of supraclavicular fatsurrogate

Brown adipose tissue is highly prevalent in adult humans and is present in supraclavicular fat even when PET-CT is negative, suggesting standard PET-CT underestimates its prevalence.

Cite This Study

Lee et al. (2011) studied this question.

synapsesocial.com/papers/6a7258d6ac440176ef2aa222 https://doi.org/10.1210/jc.2011-0487

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High Prevalence of Brown Adipose Tissue in Adult Humans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High Prevalence of Brown Adipose Tissue in Adult Humans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider