A cough model induced by sulfur dioxide gas was devised for use with mice. In this method, the ED 50 of morphine hydrochloride was 1.58 mg/kg p. o. and that of codeine phosphate was 10.28 mg/kg p. o . Using the method established, L -ephedrine hydrochloride, 0.4, 4.0 and 40 mg/kg p. o. , inhibited the cough induction in a dose-dependent manner and amygdalin, 1.0, 10 and 100 mg/kg p. o. , also inhibited the cough induction. On the other hand, treatment of Makyokansekito, 162 mg/kg p. o. , which contained Ephedrae herba ( L -ephedrine, 4.6 mg/kg) and Armeniacae semen (amygdalin, 8.4 mg/kg) as component, showed stronger antitussive effects than the individual crude drugs.
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Miyagoshi et al. (1986) studied this question.