Key result
Hypertension history is linked to ~40% lower odds of age-associated peripheral neuropathy.
Why the study?
A previous cross-sectional study found a protective association between history of hypertension and age-associated peripheral neuropathy (AAPN), warranting further investigation in the same cohort and a diabetic comparison group.
Is a history of hypertension associated with the prevalence of age-associated peripheral neuropathy in elderly patients?
Comparison
History of hypertension, antihypertensive medication classes, NSAIDs, and blood pressure metrics versus absence or non-use
Design
Cross-sectional analysis of baseline data from a longitudinal study
Follow-up
3 years
Authors
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Hypertension history was associated with lower neuropathy odds; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=584)
Yes
Is a history of hypertension associated with the prevalence of age-associated peripheral neuropathy in elderly patients?
Odds Ratio: 0.6 (95% CI 0.4–0.9)
p-value: p=0.01
A history of hypertension appears to be inversely associated with age-associated peripheral neuropathy in the elderly, while pulse pressure is positively associated with neuropathy in diabetic patients.
Cho et al. (2006) conducted a cross-sectional in Age-associated peripheral neuropathy (n=584). History of hypertension vs. No history of hypertension was evaluated on Presence of age-associated peripheral neuropathy by physical examination (OR 0.60, 95% CI 0.40 to 0.90, p=0.01). A history of hypertension was negatively associated with age-associated peripheral neuropathy (OR 0.60) in older adults without known medical causes for neuropathy.
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