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Preclinical pharmacokinetic study demonstrates simultaneous LC-MS/MS quantification of three ocular drugs in rabbit tears, highlighting an efficient tool for preclinical drug monitoring.
multiple reaction monitoring mode. The sample extraction was performed using the protein precipitation method with minimal sample size. The validated methodology was employed to determine the ocular pharmacokinetics profile of marketed formulations containing VCZ, MOXI, and PIR in rabbit lacrimal matrix.
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Bisen et al. (2023) studied this question.
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