OBJECTIVE: To assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi. METHODS: Antifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of various extracts and fractions of Ocimum sanctum leaves were also determined. RESULTS: Ocimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200 μg/mL. MIC and MFC were high with water fraction (200 μg/mL) against dermatophytic fungi used. CONCLUSIONS: Ocimum sanctum has antifungal activity, and the leaf extracts may be a useful source for dermatophytic infections.
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Balakumar et al. (2011) studied this question.
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