Key result
Autophagy inhibition blocks citrullinated peptide presentation on MHC class II molecules, linking autophagy to autoreactivity.
Why the study?
The mechanisms linking autophagy in antigen-presenting cells to presentation of citrullinated peptides involved in autoimmunity were unclear.
Autophagy in antigen-presenting cells is linked to autoreactivity through the generation and presentation of citrullinated neo-epitopes.
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Autophagy inhibition blocks citrullinated peptide presentation; hypothesis-generating for autophagy targeting in human autoimmunity.
Ireland et al. (2011) studied Rheumatoid arthritis / Autoimmunity. 3-methyladenine (3MA) / Autophagy inhibition vs. Normal culture conditions was evaluated on Presentation of citrullinated peptides on class II MHC molecules. Autophagy inhibition with 3-methyladenine blocked the presentation of citrullinated peptides on class II MHC molecules by antigen-presenting cells, linking autophagy to autoreactivity.
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