Relationship between tumor parameters in Ga-68 PSMA PET/CT and pathological grade grouping in patients with prostate cancer

Background:The study aims to explore the relationship between tumor parameters acquired from Ga-68 PSMA PET/CT and GG system in patients who had prostate cancer.Materials and Methods: One hundred and fourteen patients diagnosed with prostate cancer and who underwent Ga-68 PSMA PET/CT imaging for staging purposes were enrolled.The imaging was performed using a Siemens Biograph Horizon-3R 16 slice PET/CT device, and the tumor parameters (SUVmax, SUVmean, and Tumor volume) were calculated by an experienced nuclear medicine physician.Results: There was a correlation between GG with SUVmax (p:0.010;r:0.241) and SUVmean (p:0.06;r:0.258).In redicting high-risk patients, ROC analysis was conducted for SUVmax and SUVmean, resulting in significant cut-off values for both parameters.A cut-off value of 9.8 for SUVmax resulted in a sensitivity of 69% and a specificity of 58%.5.8 cut-off value for SUVmean resulted in 68% sensitivity and 58% specificity.Tumor volume was found to be a significant predictor for distant metastasis.When a cut-off value of 11.53 cm3 was used for tumor volume, sensitivity was found to be 62% and specificity 56%.Conclusion: According to the results, correlation between GG with SUVmax and SUVmax was significant.Additionally, SUVmax and SUVmean were significant predictors of high-risk prostate cancer, while TV was a significant predictor of distant metastases.In summary, Ga-68-PSMA PET CT are deemed a beneficial imaging modality for both prognosis assessment and staging in clinical.