Oral and subcutaneous administration of the compounds aminopropyl-aminostyrylmethoxyquinoline trihydrochloride and o-β-diethylaminoethyl harmol hydrochloride causes the appearance of peculiar bodies in the blood cells of canaries and mice. The bodies are irregular in shape and size, stain intensely blue with Leish-man's and Giemsa's stains, and are most numerous in erythrocytes, but occur also in eosinophiles, leucocytes and reticulo-endothelial cells. The bodies show no cytological structure, are not seen to undergo multiplication, and are not transmissible by blood inoculation. They are apparently non-living inclusions in the blood cells caused by the action of these two chemical compounds.
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Tate et al. (1932) studied this question.