What does this research mean for the field?

Mutant TP53 increases genomic instability and induces major pathway signaling changes across multiple cancer types. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Characterize the downstream molecular consequences and signaling pathway alterations driven by TP53 mutations across a large pan-cancer cohort.

September 1, 2019Cell ReportsOpen Access

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

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Characterize the downstream molecular consequences and signaling pathway alterations driven by TP53 mutations across a large pan-cancer cohort.
Analyzed genomic and molecular profiling data from 10,225 patients across 32 cancer types from The Cancer Genome Atlas (TCGA).
Integrated multi-omic data synthesized across five distinct analytical platforms to assess genomic instability and signaling changes.
Mutant TP53 drove substantial increases in genomic instability across multiple tumor types compared to wild-type cases.
TP53 alterations induced pervasive downstream shifts in major oncogenic signaling pathways across the evaluated cancer types.

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Implication

Genomic analysis reveals that TP53 mutations increase genomic instability across 10,225 patients in 32 cancer types, highlighting extensive downstream pathway alterations.

Cite This Study

Donehower et al. (2019) studied this question.

synapsesocial.com/papers/6aaa5d1b0d3342aa3754cc4b https://doi.org/10.1016/j.celrep.2019.08.061

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Implication

Genomic analysis reveals that TP53 mutations increase genomic instability across 10,225 patients in 32 cancer types, highlighting extensive downstream pathway alterations.

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

Key Points

Discussion

Implication

Cite This Study

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

Key Points

Discussion

Implication

Cite This Study

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