Key result
Post-cardiac arrest PCI is linked to ~54% lower 5-year mortality in survivors.
Why the study?
There is little evidence regarding how PCI and therapeutic hypothermia impact long-term prognosis after resuscitation from out-of-hospital cardiac arrest.
Do percutaneous coronary intervention and therapeutic hypothermia improve long-term survival in patients resuscitated and discharged alive following out-of-hospital cardiac arrest?
Cohort (n=1,001)
Do percutaneous coronary intervention and therapeutic hypothermia improve long-term survival in patients resuscitated and discharged alive following out-of-hospital cardiac arrest?
Hazard Ratio: 0.46 (95% CI 0.34–0.61)
Absolute Event Rate: 78.7% vs 54.4%
p-value: p=<0.001
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In patients surviving to hospital discharge after out-of-hospital cardiac arrest, the use of PCI and therapeutic hypothermia during the index hospitalization is associated with significantly improved long-term survival.
Dumas et al. (2012) conducted a cohort in Out-of-hospital cardiac arrest (n=1,001). Percutaneous coronary intervention (PCI) and therapeutic hypothermia (TH) vs. No PCI and no TH was evaluated on 5-year survival / risk of death (HR 0.46, 95% CI 0.34 to 0.61, p=<0.001). Percutaneous coronary intervention (HR 0.46; 95% CI 0.34-0.61) and therapeutic hypothermia (HR 0.70; 95% CI 0.50-0.97) were associated with lower long-term mortality in cardiac arrest survivors.
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