Ochratoxin A is a fungal metabolite which induces pathological changes in animals. The toxin was isolated from cultures of Aspergillus ochraceus and purified by thin-layer chromatography. Ochratoxin A and one of its hydrolysis products, dihydroisocoumarin, severely inhibited coupled respiration when applied at low concentration to rat liver mitochondria.
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Moore et al. (1970) studied this question.
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