Key result
Higher baseline HRV linked to ~29% lower likelihood of CAC progression.
Why the study?
Reduced heart rate variability is a manifestation of cardiac autonomic neuropathy, a known complication of type 1 diabetes, and its predictive value for coronary artery calcium progression was evaluated.
Does reduced heart rate variability predict the progression of coronary artery calcification in adults with and without type 1 diabetes?
Population
Adults aged 19 to 56 years with type 1 diabetes or without diabetes from the Coronary Artery Calcification in Type 1 Diabetes study
Comparison
Reduced versus higher heart rate variability measured by SD of consecutive RR intervals
Design
Cohort study
Follow-up
6.0 ± 0.5 years
Authors
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Supports autonomic neuropathy's role in CAC progression; leaves open whether HRV modification alters atherosclerosis risk in T1D.
Cohort
Does reduced heart rate variability predict the progression of coronary artery calcification in adults with and without type 1 diabetes?
Odds Ratio: 0.71 (95% CI 0.56–0.9)
p-value: p=0.005
Reduced heart rate variability independently predicts the progression of coronary artery calcification, supporting the role of autonomic neuropathy in the atherosclerotic process.
Rodrigues et al. (2010) conducted a cohort in Type 1 diabetes and controls without diabetes. Higher heart rate variability (HRV) vs. Lower heart rate variability was evaluated on Progression of coronary artery calcium (CAC) defined as an increase in square root transformed CAC volume of ≥ 2.5 mm(3) (OR 0.71, 95% CI 0.56-0.90, p=0.005). Higher heart rate variability at baseline was associated with a lower likelihood of coronary artery calcium progression (OR 0.71; 95% CI 0.56-0.90; P=0.005).
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