Key result
Post-translational protein citrullination and carbamylation are linked to both rheumatoid arthritis and atherosclerosis pathogenesis.
Why the study?
The role of citrullination and carbamylation in the pathogenesis of both rheumatoid arthritis and atherosclerosis and their contribution to cardiovascular disease risk in RA patients is not fully understood.
Post-translational modifications such as citrullination and carbamylation may provide a mechanistic link between rheumatoid arthritis and accelerated atherosclerosis.
Answers are grounded in this paper and cite their sources.
May link RA and atherosclerosis via shared modifications; hypothesis-generating, requires prospective validation before clinical consideration.
Coronary heart disease is the main cause of mortality in patients with rheumatoid arthritis (RA), a disease known to be associated with accelerated atherosclerosis. The role of inflammation and immunity in atherosclerotic process offers possible explanations for the increased cardiovascular risk in patients with RA. The immune response to citrullinated peptides has been extensively studied in RA; antibodies directed to citrullinated peptides are now a cornerstone for RA diagnosis. However, few studies have investigated the response to citrullinated peptides and the development of atherosclerotic plaque. Antibodies to carbamylated proteins can be detected before the clinical onset of RA, suggesting a potential predictive role for these antibodies; on the other hand, carbamylation of lipoproteins has been described in patients with cardiovascular disease. This review examines the role of citrullination and carbamylation, two post-translational protein modifications that appear to be involved in the pathogenesis of both RA and atherosclerosis, expanding the similarities between these two diseases. Further investigation on the role of the immune response to modified proteins may contribute to a better comprehension of cardiovascular disease in patients with RA.
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Spinelli et al. (2016) conducted a review in Rheumatoid arthritis and atherosclerosis. Citrullination and carbamylation was evaluated. Post-translational protein modifications, specifically citrullination and carbamylation, appear to be involved in the pathogenesis of both rheumatoid arthritis and atherosclerosis.
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