Key result
Thoracic endovascular aortic repair was associated with a significant increase in interventricular septum thickness (p=0.041) and a decrease in left ventricular ejection fraction (p=0.01).
Why the study?
The impact of thoracic endovascular aortic repair on cardiac remodeling assessed by transthoracic echocardiography was not well characterized.
Does thoracic endovascular aortic repair (TEVAR) impact cardiac remodeling in patients with thoracic aortic aneurysm?
Cohort (n=32)
Does thoracic endovascular aortic repair (TEVAR) impact cardiac remodeling in patients with thoracic aortic aneurysm?
p-value: p=0.041 for IVS; 0.01 for LVEF
TEVAR may negatively impact cardiac remodeling, evidenced by increased interventricular septum thickness and decreased LVEF, suggesting a need for more flexible endograft designs.
May warrant post-TEVAR cardiac surveillance in aneurysm patients; leaves open whether flexible endografts mitigate remodeling.
Objectives: This study aimed to evaluate post-thoracic endovascular aortic repair (TEVAR) cardiac remodeling with transthoracic echocardiography. Patients and methods: Thirty-two patients (27 males, 5 females; mean age: 61±12.8 years; range, 27 to 85 years) who underwent TEVAR, with an Ishimura zone 3 proximal landing zone, due to thoracic aortic aneurysm were retrospectively evaluated between January 2019 and January 2023. Pre- and postprocedural transthoracic echocardiography data of the patients were compared. Measurements of left ventricular end-diastolic diameter, left ventricular ejection fraction, interventricular septum, and ascending aorta were performed. Results: The mean follow-up period was 23.7±8.4 months. There was a significant increase in interventricular septum measurements (p=0.041). In addition, a significant decrement was observed in the comparison of left ventricular ejection fraction values (p=0.01). There was no difference found at the pre- and post-TEVAR ascending aortic diameters or valvular regurgitation in aortic valves. Conclusion: Despite our evaluation being conducted in a limited patient population, our findings suggest that the stiffening of the aortic structure after TEVAR has a negative impact on cardiac remodeling. Consequently, it is imperative to explore new and more flexible designs for thoracic endograft structures.
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Sabir Hasanzade (2024) conducted a cohort in Thoracic aortic aneurysm (n=32). Thoracic endovascular aortic repair (TEVAR) vs. Pre-procedural baseline was evaluated on Cardiac remodeling (interventricular septum measurements and left ventricular ejection fraction) (p=0.041 for IVS; 0.01 for LVEF). Thoracic endovascular aortic repair was associated with a significant increase in interventricular septum thickness (p=0.041) and a decrease in left ventricular ejection fraction (p=0.01).
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