Key result
Longitudinal hemostasis monitoring supports individualized anticoagulant thromboprophylaxis in high-risk pregnant women.
Why the study?
Physiological prothrombotic changes during pregnancy increase the risk of VTE and adverse pregnancy outcomes, but personalized refinements of anticoagulant thromboprophylaxis remain unspecified.
Population
High-risk pregnant women with congenital and acquired thrombophilic conditions
Comparison
Longitudinal monitoring and assessment of hemostasis to personalize anticoagulant thromboprophylaxis
Design
Review and single-center experience report
Authors
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May support individualized thromboprophylaxis in high-risk pregnancy; leaves open need for prospective validation.
Longitudinal monitoring of hemostasis may help individualize and optimize anticoagulant thromboprophylaxis in high-risk pregnant women to prevent adverse pregnancy outcomes.
Dobrotová et al. (2016) conducted a review in High-risk pregnancy with increased risk of fetal loss. Longitudinal monitoring of hemostasis and individualized anticoagulant thromboprophylaxis was evaluated. Longitudinal monitoring of hemostasis was reviewed for individualizing anticoagulant thromboprophylaxis in high-risk pregnant women, though no quantitative results were reported in the abstract.
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