Key result
Stentless mitral valve implantation demonstrates similar 5-year survival to conventional repair and replacement.
Why the study?
A chordally supported stentless mitral valve may be a suitable prosthesis for severe degenerative mitral valve disease, but comparative midterm results versus conventional repair or replacement were needed.
Does stentless mitral valve implantation improve five-year survival compared to conventional mitral valve repair or replacement in patients with severe degenerative mitral valve disease?
Cohort (n=155)
Does stentless mitral valve implantation improve five-year survival compared to conventional mitral valve repair or replacement in patients with severe degenerative mitral valve disease?
Answers are grounded in this paper and cite their sources.
Stentless mitral valve implantation offers comparable midterm survival and safety to conventional mitral valve repair or replacement for severe degenerative mitral valve disease.
OBJECTIVE: A chordally supported stentless mitral valve (SMV) may be a suitable prosthesis for patients with severe degenerative mitral valve disease. We analyzed the five-year results and compared them with results after conventional mitral valve repair or replacement. METHODS: 155 patients, operated on since August 1997, were evaluated. 53 patients (ages, 68 +/- 8 years, 37 female, valve repair not feasible) received a SMV (Quattro), 51 patients (69 +/- 9 years, 32 female) had mitral valve repair (MVR) and 51 patients (66 +/- 9 years, 32 female) had a conventional mitral valve replacement (MVP). There were no significant differences with respect to preoperative NYHA functional class, left ventricular ejection fraction, cardiac index and surgical risk, according to the EuroSCORE. Mean follow-up is 64 +/- 18 (21-89) months. RESULTS: Surgery was performed using a median sternotomy (32 [SMV]/20 [MVR]/34 [MVP]) or a lateral mini-thoracotomy 21/31/17 approach. The SMV was safely attached to the papillary muscles. In-hospital mortality was 1, 2 and 4 respectively; re-operation was required in 6, 2 and 3 patients. Five-year survival rate was 80.6 +/- 4.4 % (SMV), 80.2 +/- 5.6 % (CMV) and 82.6 +/- 5.6 % (MVP), p = n.s. After hospital discharge, there was no significant difference in mortality in comparison to an age-matched control population. Echocardiography revealed acceptable SMV hemodynamics with preservation of left ventricular function. CONCLUSION: Midterm results after SMV implantation are comparable to conventional approaches. Complete preservation of the annulo-ventricular continuity is advantageous and close to physiologic hemodynamics can be achieved. Long term follow-up is required.
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Lehmann et al. (2006) conducted a cohort in Severe degenerative mitral valve disease (n=155). Stentless mitral valve (SMV) implantation vs. Conventional mitral valve repair (MVR) or replacement (MVP) was evaluated on Five-year survival rate (p=n.s.). Stentless mitral valve implantation resulted in a 5-year survival rate of 80.6%, comparable to conventional mitral valve repair and replacement.
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