Key result
Oral glucose loading in normal individuals peaks within an hour and rarely exceeds 150 mg/dL.
Why the study?
The rate of glucose removal from blood after massive oral administration may be influenced by factors unrelated to carbohydrate metabolism, affecting blood sugar curves and pathology of disorders with lowered sugar tolerance.
What factors determine the rate of glucose removal from the blood following massive oral administration?
Population
Normal individuals
Comparison
None; factors affecting glucose removal rate after oral glucose administration
Design
Experimental study on glucose metabolism factors
Authors
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Establishes normative venous glucose response to 100g load; leaves open mechanisms of removal in disease states.
What factors determine the rate of glucose removal from the blood following massive oral administration?
This historical physiological study describes the normal blood sugar response to a 100g oral glucose load, noting a rapid peak and decline despite ongoing intestinal absorption.
Cajori et al. (1925) studied this question. Oral glucose administration was evaluated on Blood sugar level. Following oral administration of 100 gm of glucose in normal individuals, the peak of alimentary hyperglycemia is usually reached in an hour, rarely exceeding 150 mg per 100 cc in venous blood.
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