Key result
Endostar and radiotherapy shrink nodules in a primary pulmonary arterial sarcoma case, achieving 18-month survival.
Why the study?
Does endostatin injection combined with radiotherapy reduce tumor size in primary pulmonary arterial sarcoma?
Case Report (n=1)
No
Does endostatin injection combined with radiotherapy reduce tumor size in primary pulmonary arterial sarcoma?
Endostatin injection combined with radiotherapy may offer an alternative treatment strategy for primary pulmonary arterial sarcoma, a rare condition often misdiagnosed as pulmonary embolism.
Single-case report precludes practice change; leaves open endostatin-radiotherapy role in pulmonary arterial sarcoma.
A case of primary pulmonary arterial sarcoma (PPAS) treated with Endostar injection and radiotherapy and discuss the diagnosis, clinical characteristics, and pathology of PPAS. The patient complained of cough, sputum, fever, and chest pain with hemoptysis. Numerous nodules were seen in the computed tomography scan. The patient was diagnosed as pulmonary embolism (PE) by computed tomography pulmonary angiography. The pathology and immunohistochemistry results indicated soft tissue sarcomas, indicative of angiosarcoma. The nodules shrunk after 5 courses of endostatin and one course of radiotherapy, as seen by CT scan. Therefore, PPAS is clinically rare with nonspecific symptoms. Hence, it can be easily misdiagnosed as PE, biopsy for confirmation. Current treatment is limited and includes surgery. Hence, endostatin injection combined with other therapy may be an alternative treatment.
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Xu et al. (2020) conducted a case report in Primary pulmonary arterial sarcoma (n=1). Endostar injection and radiotherapy was evaluated on Tumor response and survival. Endostar injection combined with radiotherapy led to significant shrinkage of pulmonary nodules in a patient with primary pulmonary arterial sarcoma, achieving a total survival duration of 18 months.
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