Key result
Low-concentration ethanol inhibits NMDA receptors, though its link to magnesium regulation remains unclear.
Why the study?
The relationship between the acute effects of ethanol on NMDA receptor activation and the regulatory properties of Mg2+ is not yet known, with implications for receptor function in chronic alcoholism.
Population
NMDA receptors in the central nervous system
Comparison
Ethanol effects vs Mg2+ regulation on NMDA receptors
Design
Review
Authors
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Does not yet alter alcoholism management; leaves open Mg2+ modulation of ethanol's NMDA effects for mechanistic trials.
This review highlights the complex interactions between ethanol inhibition and magnesium regulation of NMDA receptors in the brain, which may have implications for chronic alcoholism.
Michaelis et al. (1994) conducted a review in Ethanol effects on brain. Ethanol was evaluated. Low concentrations of ethanol (5-50 mM) inhibit the NMDA subtype of L-glutamate receptors, though the relationship between ethanol's acute effects and Mg2+ regulation remains unknown.
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