Key result
lncRNAs regulate endothelial function in CAD, offering potential novel diagnostic and therapeutic targets.
Why the study?
Endothelial cell injury is an early feature of coronary atherosclerotic disease, and the role of lncRNAs in modulating ECs in CAD pathogenesis has recently emerged.
lncRNAs regulate endothelial cell function in coronary atherosclerotic disease, presenting potential novel targets for diagnosis and therapy.
Coronary atherosclerotic disease (CAD) is a common cardiovascular disease and an important cause of death. Moreover, endothelial cells (ECs) injury is an early pathophysiological feature of CAD, and long noncoding RNAs (lncRNAs) can modulate gene expression. Recent studies have shown that lncRNAs are involved in the pathogenesis of CAD, especially by regulating ECs. In this review, we summarize the novel progress of lncRNA-modulated ECs in the pathogenesis of CAD, including ECs proliferation, migration, adhesion, angiogenesis, inflammation, apoptosis, autophagy, and pyroptosis. Thus, as lncRNAs regulate ECs in CAD, lncRNAs will provide ideal and novel targets for the diagnosis and drug therapy of CAD.
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Ouyang et al. (2023) conducted a review in Coronary atherosclerotic disease. Long noncoding RNAs (lncRNAs) was evaluated. Long noncoding RNAs (lncRNAs) regulate endothelial cell functions in the pathogenesis of coronary atherosclerotic disease, offering potential novel targets for diagnosis and drug therapy.
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