Key result
Genetic platelet defects yield ~50% higher survival versus normal mice on an atherogenic diet.
Why the study?
The contribution of platelets to the development of atherosclerosis and the specific platelet function components involved remain unclear.
Does impaired platelet function reduce the severity of atherosclerosis in susceptible mice on an atherogenic diet?
Population
Susceptible C57BL/6 mice with normal or variant platelet function phenotypes
Comparison
Five platelet function mutants versus normal C57BL/6 mice
Design
Preclinical study with genetic platelet function variants
Follow-up
Up to 48 weeks
Authors
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Platelet defects boost survival in atherogenic mice; leaves open platelet role in human atherosclerosis.
Does impaired platelet function reduce the severity of atherosclerosis in susceptible mice on an atherogenic diet?
Absolute Event Rate: 50% vs 0%
Specific genetic defects in platelet function confer resistance to atherosclerosis and improve survival in mice fed an atherogenic diet, suggesting a role for platelets in atherogenesis.
Paigen et al. (1990) studied Atherosclerosis. Variant phenotypes for platelet function (maroon, light ear, ruby eye, beige, pale ear) vs. Normal C57BL/6 mice was evaluated on Survival at 48 weeks. Mice with specific genetic defects in platelet function (light ear and ruby eye) showed greater than 50% survival at 48 weeks compared to 0% survival in normal C57BL/6 mice.
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