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March 8, 1985Science

Platelet-Mediated Cholesterol Accumulation in Cultured Aortic Smooth Muscle Cells

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Population

Cultured rat aortic smooth muscle cells

Comparison

Incubation with thrombin-activated washed rat… vs Incubation with unactivated platelets

Design

Preclinical

Authors

HKHoward S. KruthNational Institutes of Health

Discussion

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Implication

No immediate clinical implications; leaves open a platelet role in atherogenesis pending in vivo validation.

Structured PICO

P

Population

Cultured rat aortic smooth muscle cells

I

Intervention

Incubation with thrombin-activated washed rat platelets (or platelet-free supernatants prepared from thrombin-activated platelets)

C

Comparator

Incubation with unactivated platelets

O

Outcome

Cholesteryl ester lipid droplet accumulation within the smooth muscle cellssurrogate

Activated platelets may release cholesterol that accumulates in smooth muscle cells as lipid droplets, suggesting a potential cellular mechanism contributing to atherogenesis.

Cite This Study

Howard S. Kruth (1985) studied this question.

synapsesocial.com/papers/6a75f0141078cf7de2b24b92 https://doi.org/10.1126/science.3975612

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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

1A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro1974 · 1,857 citations
2Isolation and characterization of lipid-protein particles containing platelet factor 3 released from human platelets1982 · 67 citations
3Quantification of low density lipoprotein binding and cholesterol accumulation by single human fibroblasts using fluorescence microscopy.1980 · 64 citations